SLAYTON CLINIC Logo The city of Slayton is the largest city in Murray County with a population of 2,200. Slayton is located at the junction of US Highway 75 and State Highway 30. The City is approximately 30 miles north of Interstate 90. Slayton is located about 3 hours from Minneapolis/St. Paul and 1 and half hours from Sioux Falls, SD, a community of 130,000. The Slayton area offers a wide-variety of outdoor activities including fishing, golf, hunting, and numerous water sports.